Alejandro is an aspiring toy designer from El Salvador, struggling to bring his unusual ideas to life in New York City. As time on his work visa runs out, a job assisting an erratic art-world outcast becomes his only hope to stay in the country and realize his dream.
A fateful night in 1959, four people die when the bus they are riding crashes. They continue as ghosts; their souls become eternally entwined to the life of a child born at the moment of their deaths as his guardians. Baby Thomas grows up to be a businessman who has memories of his playmates, but assumes they are products of his youthful imagination. When the ghosts realize they need Thomas' help to move on to the afterlife, they decide to make an appearance once more.
A message from Jim Morrison in a dream prompts cable access TV stars Wayne and Garth to put on a rock concert, "Waynestock," with Aerosmith as headliners. But amid the preparations, Wayne frets that a record producer is putting the moves on his girlfriend, Cassandra, while Garth handles the advances of mega-babe Honey Hornée.
After standing in as best man for his longtime friend Carl Petersen, Randy Dupree loses his job, becomes a barfly and attaches himself to the newlywed couple almost permanently -- as their houseguest. But the longer Dupree camps out on their couch, the closer he gets to Carl's bride, Molly, leaving the frustrated groom wondering when his pal will be moving out.
Admiral Frank Beardsley returns to New London to run the Coast Guard Academy, his last stop before a probable promotion to head the Guard. A widower with eight children, he runs a loving but tight ship, with charts and salutes. The kids long for a permanent home. Helen North is a free spirit, a designer whose ten children live in loving chaos, with occasional group hugs. Helen and Frank, high school sweethearts, reconnect at a reunion, and it's love at first re-sighting. They marry on the spot. Then the problems start as two sets of kids, the free spirits and the disciplined preppies, must live together. The warring factions agree to work together to end the marriage.